Preferred Label : CDAC Targeting EGFR Mutant BG-60366;
NCIt synonyms : CDAC BG-60366; Mutant EGFR-targeted CDAC BG-60366; EGFR Mutant Degrader BG-60366; EGFR Mutation-targeted Chimeric Degradation Activation Compound BG-60366;
NCIt definition : An orally bioavailable chimeric degradation activation compound (CDAC) targeting mutant
epidermal growth factor receptor (EGFR) comprised of an E3 ubiquitin ligase ligand
conjugated to an EGFR mutant-binding ligand, with potential antineoplastic activity.
Upon oral administration, CDAC targeting EGFR mutant BG-60366 specifically targets
and binds, with its mutant EGFR-targeting moiety, to mutant EGFR and the E3 ubiquitin
ligase ligand moiety binds to E3 ubiquitin ligase. This catalyzes ubiquitination and
proteasome-mediated degradation of mutant EGFR and prevents the activation of the
EGFR-mediated signaling pathway. This leads to an inhibition of the growth of EGFR
mutant-expressing tumor cells. EGFR is overexpressed or mutated in a variety of cancer
cells.;
Molecule name : BG-60366; CDAC BG 60366; CDAC BG60366;
Origin ID : C213289;
concept_is_in_subset
- has_target
