Preferred Label : RBM39 Degrader REC-1245;
NCIt synonyms : RBM39 Molecular Glue Degrader REC-1245;
NCIt definition : An orally bioavailable molecular glue degrader of the splicing factor RNA-binding
protein 39 (RNA-binding motif protein 39; RBM39), with potential antineoplastic activity.
Upon oral administration, RBM39 degrader REC-1245 induces the ubiquitination and proteasome-mediated
degradation of RBM39 via the E3 ligase adaptor DCAF15. This modulates RNA splicing,
prevents the expression of certain tumor-associated genes, and downregulates DNA damage
response (DDR) networks and cell cycle checkpoints including cyclin-dependent kinase
12 (CDK12), which may inhibit tumor cell proliferation. RBM39, overexpressed in many
cancers, plays an important role in alternative splicing and regulating the transcription
of many tumor-related genes.;
Molecule name : REC 1245; REC-1245;
Origin ID : C213269;
concept_is_in_subset
