Preferred Label : Anti-CEACAM5 Antibody-drug Conjugate BG-C477;
NCIt synonyms : Anti-CEA ADC BG-C477; Anti-CEA Antibody-drug Conjugate BG-C477; Anti-CEACAM5 ADC BG-C477;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) carcinoembryonic antigen-related cell adhesion
molecule 5 (CEACAM5; carcinoembryonic antigen; CEA; CD66e) conjugated to an as of
yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration
of anti-CEACAM5 ADC BG-C477, the monoclonal antibody moiety targets and binds to CEACAM5
expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is
released and kills the CEACAM5-expressing cancer cells through an as of yet unknown
mechanism of action. This inhibits the proliferation of CEACAM5-expressing tumor cells.
CEACAM5, a member of the CEA family of proteins that plays a key role in cell migration,
cell invasion, and cell adhesion, is overexpressed by a variety of cancer cell types.
Its expression is limited in normal. healthy, adult tissues, but is overexpressed
in various cancers.;
Molecule name : BG-C477; BG C477;
Origin ID : C213151;
concept_is_in_subset
- has_target
