Preferred Label : Lipid Nanoparticle Encapsulating hAQP1 Circular RNA RXRG001;
NCIt synonyms : Lipid Nanoparticle Encapsulating Human Aquaporin-1 Circular RNA RXRG001; LNP Encapsulating hAQP1 circRNA RXRG001;
NCIt definition : A formulation consisting of lipid nanoparticles (LNPs) encapsulating circular RNA
(circRNA) encoding human aquaporin-1 (hAQP1), with potential saliva enhancing activity.
Upon intraductal administration of LNP encapsulating hAQP1 circRNA RXRG001 to parotid
gland(s), the LNP binds to the plasma membrane and releases the circRNA into the cell.
The circRNA is then translated to produce hAQP1, which restores water permeability
of the cell and increases saliva production. This may alleviate dry mouth symptoms.
hAQP1, a water channel protein, is one of several highly conserved water channel proteins
that mediates water permeability in cells of water-transporting tissues.;
Molecule name : RXRG-001; RXRG 001;
Origin ID : C213054;
concept_is_in_subset
