Preferred Label : BZLF1 Peptide Vaccine OSU-2131;
NCIt synonyms : BZLF1-specific Peptide Vaccine OSU-2131; rh-Hsc70-BZLF1 Peptide Complex Vaccine OSU-2131;
NCIt definition : A cancer preventive vaccine composed of the synthetic peptide RAKFKQLL, which is derived
from the Epstein-Barr virus (EBV) immediate-early protein and transcriptional activator
BZLF1, and complexed with the recombinant human heat shock protein Hsc70, with potential
immunoactivating and antineoplastic activities. Upon subcutaneous administration of
the BZLF1 peptide vaccine OSU-2131, the immune system may exert a cytotoxic T-lymphocyte
(CTL)-mediated immune response against BZLF1-expressing and EBV-infected cells. This
may prevent EBV infections and the development of EBV-driven cancer cells. The Hsc70
may enhance the T-cell responses against the BZLF1 peptide.;
Molecule name : OSU-2131; OSU 2131;
Origin ID : C213053;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
