NCIt definition : A group of mycotoxins, which are most commonly produced by Aspergillus flavus and
A. parasiticus, and their toxic metabolites that are comprised of a fused coumarin-bis(dihydrofuran)
ring structure, with potential acute and chronic toxic effects. Acute exposure to
high levels of aflatoxins can cause liver damage. Chronic aflatoxin exposure results
in an increased risk for liver cancer potentially caused by DNA intercalation and
epoxide-mediated alkylation of nucleobases by aflatoxin metabolites, leading to increased
levels of DNA damage, which may cause mutations.;
Alternative definition : NCI-GLOSS: A harmful substance made by certain types of mold (Aspergillus flavus and
Aspergillus parasiticus) that is often found on poorly stored grains and nuts. Consumption
of foods contaminated with aflatoxin is a risk factor for primary liver cancer.;