Preferred Label : Anti-CD16/IL-15/Anti-CD33 Trispecific Natural Killer Cell Engager GTB-3650;
NCIt synonyms : Anti-CD16/IL15/Anti-CD33 TriKE GTB-3650; Anti-CD16/IL-15/Anti-CD33 Trispecific NK Engager GTB-3650; Anti-CD16/IL-15/Anti-CD33 Trispecific NK Cell Engager GTB-3650; Anti-CD16/IL-15/Anti-CD33 Trispecific Killer Engager GTB-3650;
NCIt definition : A trispecific natural killer (NK) cell engager comprised of an anti-cluster of differentiation
16 (CD16; FcgammaRIII) camelid nanobody, human interleukin-15 (IL-15), and an anti-CD33
single-chain variable fragment (scFv), with potential immunomodulating and antineoplastic
activities. Upon administration, anti-CD16/IL-15/anti-CD33 trispecific NK cell engager
GTB-3650 targets and binds to CD33 expressed on tumor cells and simultaneously binds
to the activating CD16 Fc receptor expressed on NK cells, thereby bringing CD33-expressing
tumor cells and NK cells together. This induces NK cell cytotoxicity specifically
against CD33-expressing tumor cells. The cytokine IL-15 promotes NK cell proliferation,
activity, survival and expansion. CD33 is expressed on normal non-pluripotent hematopoietic
stem cells and is overexpressed on myeloid leukemia cells.;
Molecule name : GTB-3650; GTB 3650;
Origin ID : C212987;
concept_is_in_subset
- has_target
