Preferred Label : PARP Gene Family;
NCIt synonyms : Poly(ADP-Ribose)Polymerase Family Gene; PARP Gene; Poly(ADP-Ribose)Polymerase Gene;
NCIt definition : A family of genes encoding enzymes that catalyze both the transfer of an adenosine
diphosphate (ADP)-ribosyl group of oxidized nicotinamide adenine dinucleotide (NAD(
)) to the carboxyl group in protein substrates and the transfer of additional ADP-ribosyl
groups to the 2'-position of the terminal adenosine moiety. This process (poly-ADP-ribosylation)
plays a role a number of cellular processes, including DNA repair, genomic stability
and the regulation of programmed cell death.;
Origin ID : C212943;
concept_is_in_subset
- gene_found_in_organism
- gene_plays_role_in_process
