Preferred Label : Sustained-release Mitomycin C Hydrogel Formulation UGN-103;
NCIt synonyms : SR MMC Hydrogel Formulation UGN-103; Mitomycin C SR Hydrogel Formulation UGN-103;
NCIt definition : A sustained-release (SR) reverse thermal (RT) hydrogel formulation containing a lyophilized
form of the antineoplastic antibiotic mitomycin C (MMC), with potential antineoplastic
activity. Upon intravesical instillation of the SR MMC hydrogel formulation UGN-103,
the liquid converts into gel form and conforms to the bladder wall, allowing MMC to
be deposited locally in the bladder to prevent the excretion of this chemotherapeutic
agent via urinary flow. In turn, MMC alkylates DNA, and produces interstrand DNA cross-links,
thereby inhibiting DNA synthesis resulting in inhibition of tumor cell proliferation.
Due to its reverse thermal-gelation properties, this gel is able to stay in a liquid
state at cold temperatures, and undergoes transition to a water-soluble gel at body
temperature. This allows for increased accumulation of MMC locally in the upper urinary
tract which leads to increased efficacy compared to standard intravesical delivery
of MMC for bladder cancer.;
Molecule name : UGN-103; UGN 103;
Origin ID : C212939;
concept_is_in_subset
