Preferred Label : Indium In 111-FL-020;
NCIt synonyms : Indium In 111-labeled FL-020; [111In]In-FL-020; [111In]-FL-020; Indium In 111 FL-020;
NCIt definition : A radioconjugate composed of FL-020, a human prostate-specific membrane antigen (PSMA)-targeting
ligand, conjugated to the radioisotope indium In 111, with potential imaging activity
during single photon emission computed tomography (SPECT)/computed tomography (PET/CT).
Upon administration of indium In 111-FL-020, FL-020 targets and binds to PSMA-expressing
tumor cells, followed by internalization and retention of the radioisotope. This allows
for imaging of PSMA-expressing tumor cells using gamma scintigraphy. PSMA, a tumor-associated
antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on prostate tumor cells as well as a variety of
other solid tumors.;
Origin ID : C212903;
concept_is_in_subset
