Preferred Label : CMV pp65 mRNA Lipid Particle Vaccine;
NCIt synonyms : pp65 RNA LPs; CMV pp65 RNA-loaded Lipid Particles; CMV pp65 RNA-LPs; CMV pp65 mRNA Vaccine; pp65 RNA LP; pp65 RNA-LP Vaccine; pp65 mRNA-loaded LPs;
NCIt definition : An off-the-shelf (OTS) lipid particle (LP)-based cancer priming vaccine containing
messenger RNA (RNA) encoding the human cytomegalovirus (CMV) matrix protein pp65 (65
kDa lower matrix phosphoprotein; UL83), with potential immunostimulatory and antineoplastic
activities. Upon administration of CMV pp65 mRNA LP vaccine, the mRNA is taken up,
translated and presented by antigen presenting cells (APCs), mainly dendritic cells
(DCs). This may result in a specific cytotoxic T-lymphocyte (CTL) response against
CMV pp65-expressing tumor cells leading to tumor cell lysis. The CMV pp65 protein
is the primary component of the enveloped subviral particle of CMV and is expressed
in certain tumor types.;
Origin ID : C212897;
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