Preferred Label : HIV Budding;
NCIt definition : HIV Budding is a process in which newly generated viral RNA and protein complexes
are assembled at, packaged in, and released from the cell surface membrane taking
a piece of the cell membrane to form their own viral membranes. To bud from infected
cells, HIV-1 employs several host proteins such as endosomal sorting protein Tsg101,
which functions in the Vps pathway. The L domain (PTAP) in the p6 domain of HIV-1
Gag interacts with the N-terminal domain of TSG101; the Vps28-binding domain of TSG101
inhibits budding.;
Origin ID : C21244;
UMLS CUI : C1512301;
Semantic type(s)
- biological_process_has_associated_location
