Preferred Label : Buffered Lidocaine;
NCIt definition : A solution of 1% lidocaine, an aminoethylamide and a prototypical member of the amide
class anesthetics, buffered with 8.4% sodium bicarbonate in a 3:1 ratio, with anesthetic
activity. Upon local injection of the buffered lidocaine, lidocaine interacts with
voltage-gated Na channels in the nerve cell membrane and blocks the transient increase
in permeability of excitable membranes to Na . This prevents the generation and conduction
of nerve impulses and produces a reversible loss of sensation. Buffered lidocaine
may reduce the pain of the local injection more than unbuffered lidocaine, may reduce
the onset time of anesthesia and may increase its duration of action.;
Origin ID : C212184;
concept_is_in_subset
