Preferred Label : Anti-BCMA/GPRC5D/CD3 Trispecific Antibody SIM0500;
NCIt synonyms : Anti-GPRC5D/Anti-BCMA/Anti-CD3 Trispecific Antibody SIM0500; GPRC5DxBCMAxCD3 Trispecific Antibody SIM0500; GPRC5D-BCMA-CD3 Trispecific Antibody SIM0500;
NCIt definition : A humanized T-cell engager and trispecific antibody targeting the two tumor-associated
antigens (TAAs) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor
superfamily member 17; TNFRSF17) and human G-protein coupled receptor family C group
5 member D (GPRC5D), and the T-cell surface antigen CD3, with potential immunomodulating
and antineoplastic activities. Upon administration, anti-BCMA/GPRC5D/CD3 trispecific
antibody SIM0500 simultaneously targets and binds to BCMA and GPRC5D expressed on
tumor cells, and CD3 expressed on T-cells. The resulting cross-linkage activates and
redirects CTLs to GPRC5D- and BCMA-expressing tumor cells. BCMA, a member of the tumor
necrosis factor receptor superfamily that is specifically overexpressed on malignant
plasma cells, plays a key role in promoting plasma cell survival. GPRC5D is overexpressed
on certain tumors, including multiple myeloma, while minimally expressed on normal,
healthy cells, and plays a key role in tumor cell proliferation.;
Molecule name : SIM 0500; SIM-0500;
Origin ID : C212167;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
