KMT2A/FOXO3 Fusion Gene

Preferred Label : KMT2A/FOXO3 Fusion Gene;

NCIt synonyms : KMT2A-FOXO3 Fusion Gene; MLL/FOXO3 Fusion Gene; KMT2A::FOXO3 Fusion Gene; MLL-FOXO3 Fusion Gene; MLL-FKHRL1 Fusion Gene; MLL/FKHRL1 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(6;11)(q21;q23) that fuses exon 1 to 7, 8, or 11 of the KMT2A gene upstream of exon 2 of the FOXO3 gene. This chromosomal rearrangement is associated with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and other lymphoproliferative diseases.;

Details

Origin ID

C212136;

concept_is_in_subset
- Pediatric Oncology Target Molecular Abnormalities Terminology [NCIt concept]
gene_encodes_gene_product
- KMT2A/FOXO3 Fusion Protein [NCIt concept]
related_to_genetic_biomarker
- FOXO3 Gene [NCIt concept]
- KMT2A Gene [NCIt concept]

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