Preferred Label : ERK1/2 Inhibitor GH55;
NCIt synonyms : ERK Inhibitor GH55; Extracellular Signal-regulated Kinase 1/2 Inhibitor GH55;
NCIt definition : An orally bioavailable and selective inhibitor of the extracellular signal-regulated
kinases 1 (ERK1) and 2 (ERK2), with potential antineoplastic activity. Upon oral administration,
ERK1/2 inhibitor GH55 specifically targets, binds to and inhibits the serine/threonine-protein
kinase activities of both ERK1 and ERK2, thereby preventing the phosphorylation of
ERK1/2 substrates and the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated
signal transduction pathways. This results in the inhibition of ERK-dependent proliferation
and survival of tumor cells. The MAPK/ERK pathway, also known as the RAS/RAF/MEK/ERK
pathway, is hyperactivated in a variety of tumor cell types due to mutations in upstream
targets. It plays a key role in the proliferation, differentiation and survival of
tumor cells.;
Molecule name : GH-55; GH 55;
Origin ID : C212066;
concept_is_in_subset
- has_target
