Preferred Label : Anti-5T4/MMAE Antibody-drug Conjugate XB010;
NCIt synonyms : Anti-5T4/MMAE ADC XB010; Anti-5T4 ADC XB010; Anti-5T4 Antibody-Drug Conjugate XB010;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the oncofetal antigen 5T4 conjugated to the auristatin derivative and microtubule-disrupting
cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity.
Upon administration of anti-5T4/MMAE ADC XB010, the anti-5T4 antibody moiety selectively
binds to tumor cells expressing 5T4. Upon binding and internalization, MMAE binds
to tubulin and inhibits its polymerization, which results in G2/M phase arrest and
induces apoptosis in 5T4-expressing tumor cells. 5T4, a transmembrane glycoprotein,
is overexpressed by a variety of cancer cell types while its expression is limited
in normal adult tissues; its expression is correlated with increased invasiveness.;
Molecule name : XB-010; XB 010;
Origin ID : C211918;
concept_is_in_subset
- has_target
