Preferred Label : NK Cell-priming Inert Tumor Cells;
NCIt synonyms : Immune Priming Cells; Natural Killer Cell-priming Inert Tumor Cells; INKmune (TM);
NCIt definition : An off-the-shelf (OTS) preparation of replication-incompetent tumor cells derived
from a human tumor cell line (INB16 cells) that are able to prime and activate endogenous
natural killer (NK) cells in vivo, with potential immunomodulating and antineoplastic
activities. Upon intravenous administration, NK cell-priming inert tumor cells, which
express multiple, essential priming signals, bind to the patient's own resting NK
cells, thereby priming and activating these NK cells. The tumor-primed NK (tpNK) cells
or tumor-killing memory-like NK cells are then able to recognize and lyse tumor cells,
including a variety of NK-resistant tumor cells. Activating ligands are often missing
from resistant tumor cells.;
Origin ID : C211695;
concept_is_in_subset
