Preferred Label : SMARCA2 Inhibitor LY4050784;
NCIt synonyms : BRM Inhibitor LY4050784; SMARCA2 Inhibitor FHD-909; BRM Inhibitor FHD-909;
NCIt definition : An orally bioavailable allosteric inhibitor of SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin subfamily A member 2 (SMARCA2; BRM), with potential antineoplastic
activity. Upon oral administration, SMARCA2 inhibitor LY4050784 targets, binds to
and inhibits the activity of SMARCA2. This may lead to the inhibition of the SWI/SNF
(BRG1/BRM-associated factor; BAF) chromatin remodeling complex, disrupt chromatin
remodeling and gene expression, and result in the downregulation of oncogenic pathways
and the inhibition of tumor cell proliferation in SWI/SNF-related matrix-associated
actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4; BRG1)-deleted
cancers. SMARCA2 and SMARCA4 are the primary ATPase components and mutually exclusive
core catalytic subunits of the SWI/SNF chromatin remodeling complex, an important
regulator of transcriptional programs and gene expression. SMARCA4 expression is absent
in certain cancer cells, and these SMARCA4-deleted cancer cells depend on SMARCA2
for survival.;
Molecule name : FHD 909; LY 4050784; FHD-909; LY-4050784;
Origin ID : C211692;
concept_is_in_subset
- has_target
