Preferred Label : PRAME-targeting TCR-engineered NK Cells;
NCIt synonyms : PRAME-TCR-NK Cells; Engineered PRAME-TCR NKs; PRAME-TCR-NKs; PRAME-targeted TCR NK Cells;
NCIt definition : A preparation of natural killer (NK) cells that are engineered to express a T-cell
receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed
antigen in melanoma (PRAME), with potential antineoplastic activity. Upon administration,
the PRAME-targeting TCR-engineered NK cells specifically recognize and bind to PRAME
expressed on cancer cells, thereby lysing the PRAME-expressing cancer cells. PRAME
is overexpressed by a variety of cancer cell types.;
Origin ID : C211619;
concept_is_in_subset
