Preferred Label : Copper Cu 64 LNTH-1363S;
NCIt synonyms : Copper Cu 64-labeled LNTH-1363S; 64Cu-LNTH-1363S; [Cu-64]RTX-1363S; 64Cu-LNTH1363S; Copper Cu 64 RTX-1363S; Copper-64-labeled LNTH-1363S; Copper Cu 64-labeled RTX-1363S;
NCIt definition : A radioconjugate composed of LNTH-1363S, a fibroblast activation protein (FAP) binding
ligand and inhibitor (FAPi) chelated to the radionuclide copper Cu 64, and an albumin-binding
moiety, with potential use as a tracer for FAP-expressing cancer-associated fibroblasts
(CAFs) during positron emission tomography/computed tomography (PET/CT). Upon administration
of copper Cu 64 LNTH-1363S, the LNTH-1363S moiety selectively targets and binds to
FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected and LNTH-1363S
binding can be assessed during PET/CT imaging. FAP, a membrane-bound dipeptidyl peptidase,
is overexpressed on CAFs in the tumor microenvironment (TME) and activated fibroblasts
in tissues undergoing extracellular matrix remodeling due to chronic inflammation,
fibrosis or wound healing. Its expression is low in normal tissues.;
Origin ID : C211535;
concept_is_in_subset
