Preferred Label : Melanocortin-4 Receptor Agonist LB54640;
NCIt synonyms : MC4R Agonist LB54640; MC4 Receptor Agonist LB54640;
NCIt definition : An orally bioavailable agonist of melanocortin-4 receptor (MC4R), with potential appetite
suppressant activity that can potentially be used in the treatment of hypothalamic
obesity. Upon oral administration, MC4R agonist LB54640 selectively targets, binds
to and activates MC4R in the brain. This activates the MC4R-mediated signaling pathway
and may suppress appetite, decrease caloric intake, increase energy expenditure, decrease
weight gain and promote weight loss. MC4 receptors in the brain are involved in regulation
of hunger, satiety, and energy expenditure.;
Molecule name : LB 54640; LB-54640;
Origin ID : C211509;
concept_is_in_subset
