Preferred Label : Protease-activated Interferon Alpha-2b Prodrug CX-801;
NCIt synonyms : Protease-activated IFN-alpha-2b Prodrug CX-801; Dually-masked Interferon Alpha-2b Probody CX-801;
NCIt definition : A dually-masked, prodrug form of the human cytokine interferon alpha-2b (IFN-alpha-2b),
composed of IFN-alpha-2b linked to dual proprietary masking peptides through protease-cleavable
linkers, with potential immunomodulatory and antineoplastic activities. Upon administration
of protease-activated IFN-alpha-2b prodrug CX-801, the linkage system is stable in
the circulation and, upon extravasation into the tumor microenvironment (TME), the
peptide mask is cleaved by tumor-associated proteases, and active IFN-alpha-2b is
released. IFN-alpha-2b binds to specific IFN cell-surface receptors. This activates
IFN-mediated signal transduction pathways and induces the transcription and translation
of genes with interferon-stimulated response elements (ISREs); the protein products
mediate immunomodulating and antiproliferative effects. The selective activation in
the TME enhances the IFN-alpha-2b-mediated immune responses against tumor cells while
sparing the unwanted effects of systemic, peripheral immune activation.;
Molecule name : CX 801; CX-801;
Origin ID : C211078;
concept_is_in_subset
