Preferred Label : AKT1 E17K Inhibitor ALTA2618;
NCIt synonyms : Mutant-selective AKT1 Inhibitor ALTA2618; AKT1 E17K-mutant Inhibitor ALTA2618;
NCIt definition : An orally bioavailable covalent inhibitor of the serine/threonine protein kinase AKT
(protein kinase B; v-akt murine thymoma viral oncogene homolog 1) isoform 1 mutation
AKT1 E17K, with potential antineoplastic activity. Upon oral administration, AKT1
E17K inhibitor ALTA2618 targets, allosterically binds to and inhibits AKT1 E17K. This
may inhibit growth of and induce apoptosis in AKT1 E17K-driven cancers. AKT1 E17K,
overexpressed in a variety of cancer cell types, drives cancer cell proliferation.
By specifically targeting the E17K mutant variant, ALTA2618 may avoid the toxicities
associated with wild-type (WT) AKT inhibition.;
Molecule name : ALTA 2618; ALTA-2618;
Origin ID : C210983;
concept_is_in_subset
- has_target
