Preferred Label : Allogeneic Gamma-delta T-lymphocytes KB-GDT-01;
NCIt synonyms : Allogeneic Gamma-delta T-cells KB-GDT-01; Deltacel (TM); Donor-derived Gamma Delta T-cells KB-GDT-01; Allogeneic Gamma Delta T-cells KB-GDT-01; Allogeneic Gamma-delta T Lymphocytes KB-GDT-01;
NCIt definition : An off-the-shelf (OTS) preparation of unmodified, donor-derived T-lymphocytes that
express only gamma chain and delta chain T-cell receptors (TCRs), with potential immunomodulating
and antineoplastic activities. Upon administration of the allogeneic gamma-delta T-lymphocytes
KB-GDT-01, these cells secrete interferon-gamma (IFN-g) and exert direct killing of
tumor cells. In addition, these cells activate the immune system to exert a cytotoxic
T-lymphocyte (CTL) response against tumor cells. Gamma-delta T-lymphocytes play a
key role in the activation of the immune system and do not require major histocompatibility
complex (MHC)-mediated antigen presentation to exert their cytotoxic effect.;
Drug name : Deltacel;
Molecule name : KB-GDT01; KB-GDT 01;
Origin ID : C210963;
concept_is_in_subset
