Preferred Label : Anti-FGFR2b/Topoisomerase-1 Inhibitor Antibody-drug Conjugate BG-C137;
NCIt synonyms : FGFR2b-targeted ADC BG-C137; Anti-FGFR2b/Top-1i Inhibitor ADC BG-C137; Anti-FGFR2b ADC BG-C137;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the fibroblast growth factor receptor 2b (FGFR2b; fibroblast growth factor receptor
2 isoform IIIb; FGFR2 IIIb) conjugated to an as of yet undisclosed topoisomerase-1
inhibitor, with potential antineoplastic activity. Upon administration of anti-FGFR2b/topoisomerase-1
inhibitor ADC BG-C137, the antibody moiety targets and binds to FGFR2b-expressing
tumor cells. Upon binding and internalization, the topoisomerase-1 inhibitor is released
and inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and
resulting in cell cycle arrest and apoptosis in tumor cells expressing FGFR2b. FGFR2b
is overexpressed on certain tumor cell types.;
Molecule name : BG-C137; BG C137;
Origin ID : C210962;
concept_is_in_subset
- has_target
