Preferred Label : Autologous Tumor Membrane Vesicles Vaccine;
NCIt synonyms : Autologous TMV-based Vaccine; Autologous Tumor-derived Membrane Vesicles Vaccine; Autologous TDMV-derived Vaccine; Autologous TMV Vaccine;
NCIt definition : An autologous personalized tumor vaccine composed of tumor membrane vesicles (TMV)
derived from the patient's own tumor cells, with potential immunostimulating and antineoplastic
activities. Upon administration of the autologous TMV vaccine, the antigenic proteins
in the vaccine are presented to the immune system and activate antigen-presenting
cells (APCs). This may stimulate the immune system to mount cytotoxic T-lymphocyte
(CTL) and helper T-lymphocyte responses against the patient's tumor cells that express
these same antigens, thereby killing the tumor cells. TCMVs contain tumor proteins
and surface antigens that can stimulate an immune response.;
Origin ID : C210956;
chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
