Preferred Label : Anti-B7-H3/Topoisomerase-1 Inhibitor Antibody-drug Conjugate BGB-C354;
NCIt synonyms : Anti-CD276 ADC BGB-C354; Antibody-drug Conjugate BGB-C354; ADC BGB-C354; Anti-B7-H3/Topoisomerase-1 Inhibitor ADC BGB-C354;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) conjugated to an as of
yet undisclosed topoisomerase-1 inhibitor, with potential antineoplastic activity.
Upon administration of anti-B7-H3/topoisomerase-1 inhibitor ADC BGB-C354, the antibody
moiety targets and binds to B7-H3-expressing tumor cells. Upon binding and internalization,
the topoisomerase-1 inhibitor is released and inhibits DNA topoisomerase I activity,
thereby inhibiting DNA replication and resulting in cell cycle arrest and apoptosis
in tumor cells expressing B7-H3. B7-H3, a type I transmembrane protein and a member
of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell
types and on various immune cells. It is a negative regulator of T-cell activation,
and its overexpression plays a key role in tumor cell invasion and metastasis.;
Molecule name : BGB C354; BGB-C354;
Origin ID : C210858;
concept_is_in_subset
- has_target
