Preferred Label : Anthrapyrazole Antineoplastic Antibiotic;
NCIt synonyms : Anthrapyrazoles; Anthrapyrazole Antibiotic;
NCIt definition : A class of antibiotics related to the anthracycline antineoplastic antibiotics. The
anthrapyrazole antibiotics intercalate into DNA and interact with topoisomerase II,
thereby inhibiting DNA replication and repair and RNA and protein synthesis. These
agents may also block cell cycle division. In the presence of electron donors, some
anthrapyrazole antibiotics cause single-strand breaks in DNA via photosensitization
by visible light. These agents are less cardiotoxic than doxorubicin. (NCI04);
Origin ID : C2107;
UMLS CUI : C1510919;
Currated CISMeF NLP mapping
- Semantic type(s)
