Preferred Label : Anti-CD138 Antibody-IFNalpha Fusion Protein QXL138AM;
NCIt synonyms : Masked Immunocytokine QXL138AM; MIC QXL138AM; CD138-targeting Immunocytokine QXL138AM;
NCIt definition : A masked immunocytokine (MIC) comprised of an immunoglobulin G1 (IgG1) antibody against
the tumor-associated antigen (TAA) syndecan-1 (CD138) that is fused to the human cytokine
interferon alpha (IFNalpha; IFN-alpha; IFNa) which is attached by a tumor-protease
cleavable linker to a peptide mask, with potential immunomodulating and antineoplastic
activities. Upon administration, the anti-CD138 antibody-IFNalpha fusion protein QXL138AM
targets and binds to CD138 expressed on tumor cells. In turn, the proteases on the
cell surface cleave the linker and remove the peptide mask from IFNalpha, thereby
enabling IFNalpha to attach to its IFN cell-surface receptor on tumor cells and immune
cells within the tumor microenvironment (TME). This initiates direct tumor cell destruction
through IFNalpha-induced apoptosis and activates IFN-mediated signal transduction
pathways and induces the transcription and translation of genes with interferon-stimulated
response elements (ISREs), which activates both innate and adaptive anti-tumor immunity.
Syndecan-1, a type 1 transmembrane proteoglycan, is overexpressed in a variety of
cancer cells and plays a key role in the regulation of cell growth. The selective
activation in the TME enhances the IFN-alpha-mediated cytolytic effect and immune
responses against tumor cells while sparing the unwanted effects of systemic immune
activation while in circulation.;
Molecule name : QXL 138AM; QXL-138AM;
Origin ID : C210489;
concept_is_in_subset
- has_target
