Preferred Label : AWZ-1066S Hydrochloride;
NCIt synonyms : Pyrido(2,3-d)pyrimidin-4-amine, 2-((3S)-3-Methyl-4-morpholinyl)-N-((2-(trifluoromethyl)-3-pyridinyl)methyl)-,
Hydrochloride (1:1); Anti-Wolbachia Agent AWZ1066S Hydrochloride;
NCIt definition : The hydrochloride salt form of AWZ-1066S, an orally bioavailable synthetic compond
that is active against the bacterium Wolbachia and that can potentially be used to
treat diseases caused by namatodes of the family Filariodidea, such as lymphatic filariasis
and onchocerciasis. Upon oral administration, the anti-Wolbachia agent AWZ1066S specifically
kills Wolbachia through an as of yet not fully identified mechanism of action (MoA).
In filarial nematodes-infected humans, adult worms need Wolbachia in order to grow,
reproduce, and survive. Targeting Wolbachia may indirectly kill the adult parasitic
worms and prevent filariasis.;
UNII : DB9H6978NV;
CAS number : 2324146-73-6;
Molecule name : AWZ-1066S;
Origin ID : C210438;
concept_is_in_subset
