Vincristine Liposomal

Preferred Label : Vincristine Liposomal;

NCIt synonyms : Vincacine; Vincristine, Liposomal; Vincristine Liposome; Lipid-Encapsulated Vincristine; Liposomal Vincristine;

NCIt definition : A liposomal formulation of Vincristine designed to reduce toxicity and improve efficacy. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI);

Drug name : Onco TCS; VincaXome;

Codes from synonyms : 537;

Details

Origin ID

C2104;

UMLS CUI

C1519991;

CISMeF manual mappings
- Vincristine liposome (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Vincristine liposomal (product) [Inactive SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Vincristine liposomal (product) [Inactive SNOMED CT concept]
- Vincristine liposome (substance) [SNOMED CT concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Beta Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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