Preferred Label : Anti-nectin-4 Antibody-drug Conjugate LY4052031;
NCIt synonyms : Anti-nectin-4/LSN3889710 ADC LY4052031; Anti-nectin-4/LSN3889710 Antibody-drug Conjugate LY4052031; Anti-nectin-4 ADC LY4052031;
NCIt definition : An antibody-drug conjugate (ADC) composed of a human monoclonal antibody directed
against the cell surface adhesion molecule and tumor-associated antigen (TAA) nectin-4
(PVRL4) conjugated, via a cleavable peptide linker, to the camptothecin analog and
topoisomerase 1 inhibitor LSN3889710, with potential antineoplastic activity. Upon
administration of the anti-nectin-4 ADC LY4052031, the anti-nectin-4 antibody moiety
targets and binds to nectin-4 expressed on tumor cells. Upon binding, internalization
and linker cleavage, LSN3889710 is released. LSN3889710 inhibits DNA topoisomerase
I activity, thereby inhibiting DNA replication and resulting in cell cycle arrest
and tumor cell apoptosis. This inhibits the proliferation of nectin-4-expressing tumor
cells. Nectin-4, an immunoglobulin-like protein belonging to the nectin family, is
overexpressed in a variety of cancers.;
Molecule name : LY 4052031; LY-4052031;
Origin ID : C209887;
concept_is_in_subset
- has_target
