Preferred Label : Trefoil Factor 1;
Obsolete resource : true;
NCIt synonyms : Breast Cancer Estrogen-Inducible Protein; Gastrointestinal Trefoil Protein pS2; Trefoil Protein 1; Tefoil Protein 1; TFF1;
NCIt definition : Encoded by human TFF1 Gene (Trefoil Family), 84-amino acid 9 kD (precursor) Trefoil
Protein 1 (one trefoil domain) is expressed in stomach and duodenum. Trefoil proteins
are stable secretory polypeptides expressed in gastrointestinal mucosa that have at
least one trefoil motif (P-type domain), a 40-amino acid domain containing three conserved
disulfides, and may protect the mucosa from insults, stabilize the mucus layer, and
affect healing of the epithelium. The exact function has not been determined, but
TFF1 may participate in gastrointestinal cell differentiation by delaying G1/S transition
and reducing apoptosis. Strong expression is also found in the regenerative tissues
surrounding ulcerous lesions of the gastrointestinal tract. (from Swiss-Prot P04155,
OMIM 113710, and NCI);
Concept status : Retired_Concept;
GenBank Accession Number : NM_003225;
Origin ID : C20986;
OMIM relation
- Semantic type(s)
