Preferred Label : Beta-glucan/Dexpanthenol/Glutamine in Mucoadhesive Polymer Hydrogel;
NCIt synonyms : Beta-glucan/Dexpanthenol/Glutamine in Mucolox (TM);
NCIt definition : A water soluble, hydrogel-based formulation containing beta-glucan, a polysaccharide
isolated from the cell walls of bacteria, plants, and fungi, dexpanthenol, an alcohol
derivative of pantothenic acid, the nonessential amino acid glutamine, and preserved
water, that can potentially be used to treat mucositis. Upon oral administration of
the beta-glucan/dexpanthenol/glutamine in mucoadhesive polymer hydrogel, the mucoadhesive
polymer hydrogel interacts with the oral mucosa and promotes contact time between
the active ingredients and the mucous membranes in the mouth while also providing
moisture and serving as a protective barrier. The additional preserved water may also
keep the oral mucosa moisturized. Dexpanthenol is converted to pantothenic acid (vitamin
B5) which is required for coenzyme A synthesis as well as for the metabolism of proteins,
carbohydrates, and fats. Coenzyme A is involved in fatty acids and sphingolipids synthesis
crucial for cell membrane integrity. Dexpanthenol may promote cell proliferation and
epithelial remodeling and may provide a protective and healing effect on the oral
mucosa. Beta-glucan may stimulate the immune system, may protect against pathogens
and may prevent inflammation. Glutamine may also help maintain the integrity of the
oral mucosa, prevent cellular damage, and improve cellular recovery. Altogether, this
may prevent or reduce radiation/chemotherapy-induced mucositis.;
Origin ID : C209811;
concept_is_in_subset
