Preferred Label : Anti-NaPi2b/Exatecan Antibody-drug Conjugate TUB-040;
NCIt synonyms : Anti-NaPi2b/Exatecan ADC TUB-040; ADC TUB-040; Anti-NaPi2b ADC TUB-040; Anti-NaPi2b Antibody-drug Conjugate TUB-040;
NCIt definition : An antibody-drug conjugate (ADC) composed of a Fc-silenced, humanized immunoglobulin
G1 (IgG1) monoclonal antibody directed against human sodium-dependent phosphate transport
protein 2B (SLC34A2; NaPi2b), conjugated, via a cleavable linker, to the camptothecin
analog and topoisomerase 1 inhibitor exatecan, with potential antineoplastic activity.
Upon administration of anti-NaPi2b/exatecan ADC TUB-040, the antibody moiety targets
and binds to NaPi2b expressed on tumor cells. Upon binding, cellular uptake and linker
cleavage, exatecan is released. Exatecan inhibits DNA topoisomerase I activity, thereby
inhibiting DNA replication and generating DNA single- and double-strand breaks. This
leads to cell cycle arrest and tumor cell apoptosis. In addition, ADC TUB-040 is able
to induce a bystander effect on neighboring tumor cells. This inhibits the proliferation
of NaPi2b-expressing tumor cells. NaPi2b, a tumor-associated antigen (TAA), is overexpressed
on a variety of cancer cells and plays a key role in the transport of inorganic phosphate
(Pi) and the maintenance of phosphate homeostasis.;
Molecule name : TUB-040; TUB 040;
Origin ID : C209761;
concept_is_in_subset
- has_target
