Preferred Label : Platform Trial;
NCIt definition : A type of trial conducted under a master protocol and designed to test multiple, targeted
therapies that may be adapted over the course of the study. Platform trials often
include an adaptive design that may eliminate or add treatments based on interim analysis.
These trials may also include elements of basket or umbrella trials and may have no
pre-determined end date.;
Alternative definition : MRCT-Ctr: A research study that tests and compares two or more study treatments for
a disease or condition, with study treatment groups being added or removed during
the study period. (https://mrctcenter.org/glossaryterm/platform-trial/); CDISC-GLOSS: A type of trial conducted under a master protocol and designed to test
multiple, targeted therapies that may be adapted over the course of the study. NOTE:
Platform trials often include an adaptive design that may eliminate or add treatments
based on interim analysis. These trials may also include elements of basket or umbrella
trials and may have no pre-determined end date. [After Woodcock J, LaVange LM. Master
Protocols to Study Multiple Therapies, Multiple Diseases, or Both. N Engl J Med. 2017
Jul 6;377(1):62-70.; After US FDA, Master Protocols: Efficient Clinical Trial Design
Strategies to Expedite Development of Oncology Drugs and Biologics Guidance for Industry,
2022] See also master protocol, adaptive design, platform trial design.;
Origin ID : C209468;
concept_is_in_subset
