Preferred Label : Basket Trial;
NCIt definition : A type of trial conducted under a master protocol and designed to test a single investigational
drug or drug combination in different populations defined by disease stage, histology,
number of prior therapies, genetic or other biomarkers, or demographic characteristics.;
Alternative definition : CDISC-GLOSS: A type of trial conducted under a master protocol and designed to test
a single investigational drug or drug combination in different populations defined
by disease stage, histology, number of prior therapies, genetic or other biomarkers,
or demographic characteristics. [After US FDA, Master Protocols: Efficient Clinical
Trial Design Strategies to Expedite Development of Oncology Drugs and Biologics Guidance
for Industry, 2022; Woodcock J, LaVange LM. Master Protocols to Study Multiple Therapies,
Multiple Diseases, or Both. N Engl J Med. 2017 Jul 6;377(1):62-70.]. See also basket
trial design, adaptive design, master protocol.; MRCT-Ctr: A research study that tests one study treatment for different diseases and
conditions. (https://mrctcenter.org/glossaryterm/basket-trial/);
Origin ID : C209461;
concept_is_in_subset
