Preferred Label : Antagonistic Effect;
NCIt definition : An interaction between bioactive compounds or drugs that is deemed to be less than
the sum of each individual component.;
Alternative definition : CDISC-GLOSS: An interaction between bioactive compounds or drugs that is deemed to
be less than the sum of each individual component. NOTE: The terms additivity, synergism,
and antagonism should be used with care, unless the specific pharmacological pathways
or mechanisms of action of the investigated drugs are known. [After Calzetta L, Koziol-White
C. Pharmacological interactions: Synergism, or not synergism, that is the question.
Curr Res Pharmacol Drug Discov. 2021 Aug 11;2:100046.] See also synergistic effect,
antagonistic effect, drug interaction.;
Origin ID : C209460;
concept_is_in_subset
