Preferred Label : Autologous Anti-CD3/Anti-EGFR Bispecific Antibody Armed Peripheral Blood Mononuclear
Cells;
NCIt synonyms : EGFR Fresh PBMC; Autologous Anti-EGFR/Anti-CD3 Bispecific Antibody Armed PBMCs; EGFR FPBMC; Autologous CD3 x EGFR Bispecific Antibody Armed PBMCs; Autologous Anti-CD3/EGFR Bispecific Antibody Armed PBMCs; EGFRBi Armed Fresh PBMC; Autologous Anti-CD3/Anti-EGFR Bispecific Antibody Armed PBMCs;
NCIt definition : A preparation of autologous peripheral blood mononuclear cells (PBMCs) in which T-lymphocytes
are coated with a bispecific antibody directed against the tumor-associated antigen
(TAA) human epidermal growth factor receptor (EGFR; HER1; ErbB1) and the T-cell surface
antigen CD3 and activated ex vivo, with potential immunomodulating and antineoplastic
activities. Upon reintroduction into the patient, the autologous anti-CD3/anti-EGFR
bispecific antibody armed PBMCs target, bind to and selectively cross-link CD3-expressing
T-cells and EGFR-expressing tumor cells. This results in the activation of cytotoxic
T-lymphocytes (CTLs) and selective cytotoxicity towards the EGFR-expressing tumor
cells. EGFR, a receptor tyrosine kinase, is overexpressed on the surfaces of various
tumor cell types.;
Origin ID : C208368;
concept_is_in_subset
- has_target
