Preferred Label : MicroRNA-10b Antagomir-Iron Oxide/Dextran-based Nanoparticle TTX-MC138;
NCIt synonyms : MicroRNA-10b Inhibitor TTX-MC138; miR-10b Antagomir-containing Iron Oxide-based Nanoparticle TTX-MC138; MicroRNA-10b-targeted Nanoparticle-based Formulation TTX-MC138; miR-10b Inhibitor TTX-MC138; Anti-miR-10b Nanoparticle TTX-MC138;
NCIt definition : A nanoparticle-based formulation containing an antagomir and oligonucleotide targeting
microRNA-10b (miR-10b) encapsulated within a nanoparticle consisting of an iron oxide
core that is coated with dextran, with potential antineoplastic activity. Upon administration
of microRNA-10b antagomir-iron oxide/dextran-based nanoparticle TTX-MC138, the anti-miR-10b
moiety targets and binds to miR-10b inside tumor cells. This inhibits miR-10b and
kills miR-10b-overexpressing tumor cells. This may inhibit tumor progression and metastasis.
miR-10b, a non-coding RNA that is highly expressed in a variety of metastatic tumor
cells, plays a key role in tumor cell migration, invasion and metastasis. The dextran
coated iron oxide nanoparticles allow for an increased half-life, decreased clearance
and increased tumor cell uptake.;
Molecule name : TTX MC138; TTX-MC138;
Origin ID : C208344;
concept_is_in_subset
- has_target
