Preferred Label : Autologous SIRPa-depleted Activated Macrophages SI-101;
NCIt synonyms : Autologous SIRPa-low Macrophages SI-101;
NCIt definition : A preparation of autologous macrophages that are ex vivo activated and depleted of
signal-regulatory protein alpha (SIRP-alpha; SIRPa; CD172a), with potential immunostimulatory
and antineoplastic activities. Upon reintroduction into the patient, autologous SIRPa-depleted
activated macrophages SI-101 elicits an anti-tumor immune response via the phagocytosis
of tumor cells. In addition, the autologous SIRPa-depleted activated macrophages SI-101
promotes a pro-inflammatory tumor microenvironment (TME) and activates a cancer neoantigen-specific
cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response. The depletion of
SIRPa, an inhibitory protein expressed on macrophages and dendritic cells (DCs), prevents
SIRPa/CD47-mediated inhibition of macrophage activity.;
Drug name : SIRPant-M;
Molecule name : SI-101; SI 101;
Origin ID : C208268;
concept_is_in_subset
