Preferred Label : Anti-B7-H3 Antibody-drug Conjugate DB-1311;
NCIt synonyms : Anti-B7-H3 ADC BNT324; Anti-B7-H3/P1021 ADC DB-1311; Anti-B7-H3/Topoisomerase I Inhibitor ADC DB-1311; Anti-B7-H3 Antibody-drug Conjugate BNT324; Anti-B7-H3/TOP1i ADC DB-1311; Anti-B7-H3 ADC DB-1311;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed
against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) conjugated, via
a cleavable linker, to the topoisomerase-1 inhibitor (TOP1i) P1021, with potential
antineoplastic activity. Upon administration of anti-B7-H3 ADC DB-1311, the anti-B7-H3
antibody moiety targets and binds to B7-H3-expressing tumor cells. Upon binding, internalization
and linker cleavage, P1021 is released, and inhibits DNA topoisomerase-1 activity,
thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell
apoptosis. This inhibits the proliferation of B7-H3-expressing tumor cells. B7-H3,
a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily,
is overexpressed on certain tumor cell types and on various immune cells. It is a
negative regulator of T-cell activation and its overexpression plays a key role in
tumor cell invasion and metastasis.;
Molecule name : BNT 324; DB 1311; DB-1311; BNT-324;
Origin ID : C208267;
concept_is_in_subset
- has_target
