Preferred Label : Oncolytic Adenovirus GM103;
NCIt synonyms : Oncolytic Virus GM103;
NCIt definition : An oncolytic adenovirus, with potential antineoplastic and immunomodulating activities.
Upon intratumoral administration of oncolytic adenovirus GM103, the oncolytic virus
specifically infects and replicates in cancer cells without being able to infect and
replicate in normal, healthy cells. This induces selective oncolytic virus-mediated
cytotoxicity in cancer cells, which leads to cancer cell lysis. The released virus
particles, in turn, infect and replicate in neighboring tumor cells, thereby further
killing tumor cells. Tumor antigens released from the lysed tumor cells also activate
the immune system to induce a tumor-specific systemic immune response, thereby inducing
a cytotoxic T-lymphocyte (CTL)-mediated immune response and killing nearby non-infected
tumor cells.;
Molecule name : GM 103; GM-103;
Origin ID : C208077;
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