Preferred Label : Anti-BCMA/GPRC5D/CD3 Trispecific Antibody MBS314;
NCIt synonyms : T-cell Engager MBS314; BCMA x GPRC5D x CD3 Trispecific Antibody MBS314; TCE MBS314; Anti-BCMA/Anti-GPRC5D/Anti-CD3 Trispecific Antibody MBS314;
NCIt definition : A T-cell engager and trispecific antibody targeting the two tumor-associated antigens
(TAAs) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily
member 17; TNFRSF17) and human G-protein coupled receptor family C group 5 member
D (GPRC5D), and the T-cell surface antigen CD3, with potential immunomodulating and
antineoplastic activities. Upon administration, anti-BCMA/GPRC5D/CD3 trispecific antibody
MBS314 simultaneously targets and binds to BCMA and GPRC5D expressed on tumor cells,
and CD3 expressed on T-cells. The resulting cross-linkage activates and redirects
CTLs to GPRC5D- and BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis
factor receptor superfamily that is specifically overexpressed on malignant plasma
cells, plays a key role in promoting plasma cell survival. GPRC5D is overexpressed
on certain tumors, including multiple myeloma, while minimally expressed on normal,
healthy cells, and plays a key role in tumor cell proliferation.;
Molecule name : MBS-314; MBS 314;
Origin ID : C208070;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
