Preferred Label : N-Acetylserotonin;
NCIt synonyms : N-Acetyl Serotonin; 5-Hydroxymelatonin; Acetyl-5-Hydroxy-Tryptamine; Normelatonin; NAS; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]acetamide; N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)acetamide; 5-Hydroxy-N-Acetyltryptamine; O-Demethylmelatonin; N-Acetyl-5-HT; N-Acetyl-5-Hydroxytryptamine;
NCIt definition : A naturally occurring intermediate in the endogenous production of melatonin from
serotonin. N-acetylserotonin (NAS) binds to and activates both melatonin receptors
and BDNF/NT-3 growth factors receptor (NTRK2; TrkB). NAS-dependent melatonin receptor
signaling may ameliorate aging-associated cognitive decline and depression, while
NAS binding to TrkB may induce proliferation of neural progenitor cells, which may
elicit anti-depressant and neurotrophic effects.;
UNII : P4TO3C82WV;
CAS number : 1210-83-9;
ChEBI ID : CHEBI:17697;
Origin ID : C207956;
concept_is_in_subset
