Preferred Label : ADAM Family Gene;
NCIt definition : ADAMs (A Disintegrin and Metalloproteinase Domain) are membrane-anchored proteases
that regulate cell behavior by proteolytically modifying the cell surface and extracellular
matrix. Currently, the ADAM family has 29 members, although the function of most ADAM
gene products is unknown. The ADAM gene products with known functions act in a highly
diverse set of biological processes, including fertilization, neurogenesis, myogenesis,
embryonic TGF-alpha release and the inflammatory response. (from J Cell Biol 2002;159:893-902
and NCI);
Origin ID : C20791;
UMLS CUI : C1332022;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
