Solute Carrier Family 12 Member 3

Preferred Label : Solute Carrier Family 12 Member 3;

NCIt synonyms : Na-Cl Cotransporter; NCC; Thiazide-Sensitive Na-Cl Cotransporter; Na-Cl Symporter; SLC12A3; Thiazide-Sensitive Sodium-Chloride Cotransporter;

NCIt definition : Solute carrier family 12 member 3 (1021 aa, 113 kDa) is encoded by the human SLC12A3 gene. This protein plays a role in sodium and chloride reabsorption by distal convoluted tubules in the kidneys.;

NCIt note : Solute carrier family 12 member 3 is targeted by thiazide diuretics, which are used for treating high blood pressure. (EntrezGene);

Details

Origin ID

C207892;

OMIM relation
- Solute carrier family 12 (sodium/chloride transporter), member 3 [OMIM gene]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- SLC12A3 Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Distal Convoluted Tubule [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Solute Carrier Family [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Homeostatic Process [NCIt concept]
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]

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