Preferred Label : Wnt Signaling Inhibitor APL-5125;
NCIt synonyms : Kinase Inhibitor APL-5125;
NCIt definition : An orally bioavailable small molecule kinase inhibitor of the Wnt signaling pathway,
with potential antineoplastic activity. Upon oral administration, Wnt signaling inhibitor
APL-5125 targets and binds to an as of yet undisclosed kinase in the Wnt signaling
pathway, thereby preventing Wnt-mediated signaling. This may inhibit growth of tumor
cells in which the Wnt signaling pathway is overactivated. The Wnt signaling pathway
is upregulated in many cancers and plays a key role in tumor cell proliferation.;
Molecule name : APL 5125; APL-5125;
Origin ID : C207406;
concept_is_in_subset
