Preferred Label : Docetaxel Formulation BH009;
NCIt definition : An injectable polysorbate 80-free formulation containing the taxane docetaxel, a semisynthetic
analogue of paclitaxel, with antineoplastic activity. Upon administration of the docetaxel
formulation BH009, docetaxel binds specifically to the beta-tubulin subunit of the
microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results
in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic
factors such as vascular endothelial growth factor (VEGF) and induces various mediators
of the inflammatory response. Docetaxel formulation BH009 is formulated without polysorbate
80 which reduces the incidence and severity of hypersensitivity reactions.;
Molecule name : BH 009; BH-009;
Origin ID : C207273;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
